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目的:探讨EGFR、Akt、Raf-1、ERK mRNA在上皮性卵巢癌组织中表达的临床意义、相关性及对预后的影响。方法:用逆转录聚合酶链反应(RT-PCR)技术检测14例正常卵巢组织、16例卵巢良性肿瘤组织及61例上皮性卵巢癌组织中EGFR、Akt、Raf-1、ERK mRNA的表达,并分析它们与临床病理参数之间的关系及其相关性。结果:卵巢癌组织中EGFR、Akt、Raf-1、ERK阳性表达率显著高于正常卵巢及卵巢良性肿瘤组织(P<0.05);EGFR、Akt表达水平与卵巢癌手术病理分期、细胞学分级及淋巴结转移有关(P<0.05),Raf-1表达水平与手术病理分期及淋巴结转移有关(P<0.05);ERK表达水平与细胞学分级有关(P<0.05);两两比较,EGFR与Raf-1,Akt与Raf-1,Akt与ERK,Raf-1与ERK mRNA的表达呈正相关(P<0.05)。结论:上皮性卵巢癌组织EGFR、Raf-1、Akt、ERK的过表达与卵巢癌的发生发展及侵袭有关,可能为多靶点联合治疗提供新方向。
Objective: To investigate the clinical significance, correlation and prognosis of EGFR, Akt, Raf-1 and ERK mRNA in epithelial ovarian cancer. Methods: The expressions of EGFR, Akt, Raf-1 and ERK mRNA in 14 cases of normal ovarian tissue, 16 cases of ovarian benign tumor and 61 cases of epithelial ovarian cancer were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) And analyze their relationship with clinical pathological parameters and their correlation. Results: The positive rates of EGFR, Akt, Raf-1 and ERK in ovarian cancer tissues were significantly higher than those in normal ovarian and benign ovarian tissues (P <0.05). The expressions of EGFR and Akt were correlated with the pathological stage, (P <0.05). The expression level of Raf-1 was correlated with the pathological stage and lymph node metastasis (P <0.05). The expression level of ERK was correlated with the cytological grade (P <0.05) 1, Akt and Raf-1, Akt and ERK, Raf-1 and ERK mRNA expression was positively correlated (P <0.05). Conclusion: The overexpression of EGFR, Raf-1, Akt and ERK in epithelial ovarian cancer is related to the development and invasion of ovarian cancer, which may provide a new direction for multi-target combination therapy.