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目的 探讨注意缺陷多动障碍 (ADHD)患儿血清生长激素 (GH)和催乳素 (PRL)水平在可乐定激发前后的变化。方法 将 47例ADHD患儿按年龄分为儿童组 (35例 ) ,青少年组 (12例 ) ,并按症状分为注意障碍亚组 (2 1例 )和多动 混合亚组 (2 6例 ) ;采用放射免疫分析法 ,于可乐定激发试验前、激发后 12 0min、180min测定GH及PRL水平的变化 ,并与 10名正常儿童 (对照组 )进行比较。结果 (1)儿童组、青少年组与对照组间血清GH、PRL水平在试验各时点的差异均无显著性 (P >0 0 5 )。表现形式为 ,可乐定激发后 12 0min时 ,三组GH水平均高于激发前 ,PRL均低于激发前 ;激发后 180min时 ,儿童组和对照组GH下降 ,青少年组持续上升 ;儿童组PRL下降 ,青少年组和对照组回升。 (2 )ADHD多动 混合亚组 12 0min时的GH水平 [(12 2 6± 6 6 3) μg/L]高于注意障碍亚组 [(6 16±4 5 9) μg/L ;t=3 5 8,P =0 0 1) ]。结论 有多动、冲动行为ADHD患儿的肾上腺受体对可乐定激发更敏感
Objective To investigate the changes of serum growth hormone (GH) and prolactin (PRL) levels in children with attention deficit hyperactivity disorder (ADHD) before and after clonidine stimulation. Methods A total of 47 children with ADHD were divided into three groups according to age: children group (35 cases) and adolescent group (12 cases). According to symptoms, they were divided into two groups: attention deficit subgroup (21 cases) and hyperactivity subgroup The levels of GH and PRL were measured by radioimmunoassay before onset of clonidine challenge and after 120 minutes and 180 minutes of stimulation, respectively, and compared with 10 normal children (control group). Results (1) The serum GH and PRL levels in children, adolescents and controls were not significantly different at different time points (P> 0.05). The manifestations were as follows: after 120 min of clonidine stimulation, the levels of GH in all three groups were significantly higher than those before stimulation, and the levels of GH in children and controls were decreased at 180 min after challenge; the levels of PRL Decline, adolescent group and control group rebounded. (2) The level of GH at 120 min in ADHD hyperactivity mixed subgroup was (12 2 6 ± 6 6 3) μg / L higher than that in subgroup of ADHD [(6 16 ± 459) μg / L; t = 3 5 8, P = 0 0 1)]. Conclusion There is hyperactivity and impulsivity adrenal receptors in children with ADHD are more sensitive to clonidine stimulation