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本文说明三环抗抑郁剂因其赋形剂、给药方式的不同,可影响药物的生物利用度。药物剂量不足、治疗时间过短是治疗失效的常见原因之一。血药浓度与疗效密切相关,影响血药浓度的各种因素均可影响疗效。本文并提出应用药物代谢动力学预测最佳给药方案。
This article shows that tricyclic antidepressants can affect the bioavailability of drugs because of their different excipients and modes of administration. Insufficient drug dosage and short treatment times are one of the common causes of treatment failure. Blood concentration and efficacy are closely related to various factors that affect blood concentration can affect the efficacy. This article also proposes the application of pharmacokinetics to predict the optimal dosing regimen.