【摘 要】
：
本工作选用健康雄性Wistar大鼠,以放射免疫测定法(RIA),观察了在高海拔地区长期低氧环境中,大鼠海马(Hippocampus),下丘脑(Hypothalamus),中脑(Mesencephalon)β—内啡肽免疫
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本工作选用健康雄性Wistar大鼠,以放射免疫测定法(RIA),观察了在高海拔地区长期低氧环境中,大鼠海马(Hippocampus),下丘脑(Hypothalamus),中脑(Mesencephalon)β—内啡肽免疫活性物质(β—EPLI)含量的变化。结果表明,海马中脑内β—EPLI含量与平原对照组相比,下降有非常显著性意义(P<0.01),下丘脑下降亦有显著性差异(P<0.05)。这提示,在高海拔地区慢性缺氧条件下大鼠脑内β—EPLI可能参与其对低氧刺激的长期适应调节过程。
In this study, healthy male Wistar rats were selected and their radioimmunoassay (RIA) was used to observe the effects of Hippocampus, Hypothalamus, Mesencephalon β- Changes in the content of endorphin immunoreactive substance (β-EPLI). The results showed that the content of β-EPLI in the hippocampus was significantly decreased compared with the control group (P <0.01), and the hypothalamic decrease was also significant (P <0.05). This suggests that β-EPLI may be involved in long-term adaptive regulation of hypoxic stimulation in rats under chronic hypoxic conditions at high altitude.
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