目的研究重组链激酶（ｒＳＫ）在脑室内出血治疗中的应用。方法对１５例重度脑室内出血（ＩＶＨ），于发病后１６小时内进行双侧或单侧脑室外引流术，并辅以ｒＳＫ脑室内纤溶治疗。结果ＣＴ复查示，１４例于术后４日脑室内积血减少约６０％，７例积血１周内完全消失，７例于２周内消失，１例死亡，随访１３例中优良１１例，脑积水３例行脑室腹腔分流术。结论早期脑室外引流及应用ｒＳＫ纤溶治疗重度ＩＶＨ效果良好，无明显副反应发生。 Objective To study the application of recombinant streptokinase (rSK) in the treatment of intraventricular hemorrhage. Methods Fifteen patients with severe intraventricular hemorrhage (IVH) were treated with bilateral or unilateral ventricular drainage within 16 hours after onset and supplemented with rSK intracerebroventricular fibrinolysis. Results The CT findings showed that in 14 cases, the intracerebral hemorrhage was reduced by 60% on the 4th day after operation. The hemorrhage in 7 cases disappeared completely in 1 week, 7 cases disappeared in 2 weeks, 1 died and 11 cases were followed up , 3 cases of hydrocephalus ventriculoperitoneal shunt. Conclusion Early intraventricular drainage and application of r  SK fibrinolytic treatment of severe IVH good effect, no obvious side effects.