目的:评价 CT 导引下肺内小结节灶穿刺活检对诊断的价值。材料和方法:搜集 CT 导引下肺内病变穿刺活检182例,其中46例为肺内小结节灶,结节直径5～10mm 5例,11～15mm 20例,16～20mm 21例,共49个结节行50次活检,均在 CT 导引下进行。结果:49个结节均被刺中,诊断正确率为96%。假阴性为6.9%。无假阳性,气胸发生率为12%,无1例需放置闭式引流。结论:CT 导引下肺内小结节穿刺活检正确率高,并发症少,可作为肺内孤立性小结节灶组织学诊断的首选方法。 Objective: To evaluate the diagnostic value of CT guided pulmonary nodules biopsy. Materials and Methods: Totally 182 pulmonary biopsy specimens were collected under the guidance of CT. Among them, 46 were nodular pulmonary nodules with nodules of 5 to 10 mm in diameter, 20 of 11 to 15 mm and 21 to 16 mm of 20 mm in total Fifty-nine biopsies of 49 nodules were performed under CT guidance. Results: 49 nodules were stabbed, the diagnostic accuracy was 96%. False negative was 6.9%. No false positive, the incidence of pneumothorax was 12%, no need to place a closed drainage. CONCLUSION: CT-guided small nodules in the lungs have the high accuracy and few complications, which can be used as the first choice for the histological diagnosis of solitary small nodules in the lung.