随着临床药物的种类和剂量的不断增加以及药物间相互作用,药物对临床化学尤其是酶学检验结果直接或间接地干扰,理应引起临床医师们足够的重视。本文就这一问题,做如下概述。一、转氨酶(AST、ALT):许多药物可损害肝细胞导致AST、ALT活力不同程度的增高。药物的代谢转化主要靠肝中微粒体酶——肝药酶,而有些药物是诱导肝药酶氧化抑制,导致被氧化的药物蓄积,使肝细胞的毒害作用增加,如氯霉素可抑制肝药酶,使药物代谢转化不能正常进行。最终使 With the increase of the types and doses of clinical drugs and the interaction between drugs, the interference of drugs directly or indirectly with clinical chemistry, especially the enzymology test results should attract enough attention of clinicians. This article on this issue, make the following overview. A transaminase (AST, ALT): Many drugs can damage liver cells leading to AST, ALT vitality increased to varying degrees. Metabolic transformation of drugs mainly rely on liver microsomal enzymes - liver enzyme, and some drugs are induced liver enzyme inhibition of oxidation, resulting in the accumulation of oxidized drugs, so that the toxic effects of hepatocytes increased, such as chloramphenicol can inhibit the liver Drug enzymes, so that drug metabolism can not be normal conversion. Finally make