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目的:观察局部晚期食管癌同步放化疗后血清C-反应蛋白(CRP)水平的变化,分析CRP水平与急性放射性食管炎的相关性。方法:对35例局部晚期食管癌患者给予调强放疗同步顺铂+氟尿嘧啶方案化疗。在患者治疗前及治疗后1周抽血测血清CRP水平。急性放射性食管炎按RTOG急性放射性损伤标准评价。对血清CRP水平与放射性食管炎的关系进行统计学分析。结果:患者治疗前、后CRP分别为(16.9±11.2)mg·L-1和(25.34±11.65)mg·L-1,治疗后CRP明显升高(P<0.05);患者治疗后CRP及CRP升高水平与放射性食管炎的严重程度相关(P<0.05)。结论:局部晚期食管癌患者行同步放化疗后血清CRP升高,且CRP升高在一定程度上可预测放射性食管炎的严重程度。
Objective: To observe the changes of serum C-reactive protein (CRP) level after concurrent chemoradiotherapy in locally advanced esophageal cancer and to analyze the correlation between CRP level and acute radiation esophagitis. Methods: Twenty-five patients with locally advanced esophageal cancer received intensity modulated radiotherapy plus cisplatin plus fluorouracil regimen. Serum CRP levels were measured before treatment and 1 week after treatment. Acute esophagitis according to RTOG acute radioactive injury evaluation criteria. The relationship between serum CRP level and esophagitis was statistically analyzed. Results: The CRP levels in patients before and after treatment were (16.9 ± 11.2) mg · L-1 and (25.34 ± 11.65) mg · L-1, respectively, and the CRP levels were significantly increased after treatment (P <0.05) Elevated levels correlated with the severity of radiation esophagitis (P <0.05). CONCLUSIONS: Serum CRP is elevated in patients with locally advanced esophageal cancer after concurrent chemoradiotherapy. Elevated CRP may predict the severity of radiation esophagitis to a certain extent.