冠状动脉狭窄程度的轻重不仅与冠心病的病理生理学、解剖学、血液动力学、药理学有关,而且与冠心病的诊断、治疗与预后有关。因此,建立冠状动脉狭窄的实验模型,研究在冠脉狭窄条件下心脏的生理、病理生理、药理学等的变化,是当今冠心病基础与临床研究所迫切需要解决的一个重要课题。长期以来,国内外学者致力于高胆固醇饲养动物,以期使冠脉发生粥样硬化而仿制人类冠心病;但实验表明,此法仅能使动 Coronary artery stenosis severity not only with the pathophysiology of coronary heart disease, anatomy, hemodynamics, pharmacology, but also with the diagnosis of coronary heart disease, treatment and prognosis. Therefore, to establish an experimental model of coronary artery stenosis and to study the changes of cardiac physiology, pathophysiology and pharmacology under the condition of coronary stenosis is an urgent issue that needs to be solved urgently in the basic and clinical research institute of coronary heart disease today. For a long time, domestic and foreign scholars devoted themselves to raising cholesterol in animals in order to make coronary atherosclerosis and imitation of human coronary heart disease; but experiments show that this method can only make the move