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大量实验证据表明,T细胞对自身免疫性疾病有某种联系,这些有关疾病包括系统性红斑狼疮(SLE)、胰岛素依赖性糖尿病(IDDM)和甲状腺自身免疫性疾病等.随着对T细胞免疫识别认识的深入,也开始从蛋白质和基因水平分析T细胞抗原受体(TCR)对自身免疫性疾.病的病理影响,人的TCR是80～90K的异二聚体,通过二硫键将两条糖化的肽链(α、β链)连接,TCR属于免疫球蛋白(Ig)基因族成员,因而其肽链来源、分布及基因重组均与后者相似.
Numerous experimental evidences indicate that T cells have some connection to autoimmune diseases such as systemic lupus erythematosus (SLE), insulin-dependent diabetes mellitus (IDDM) and thyroid autoimmune diseases, etc. As T cells are immunized Recognition of the depth, but also from the protein and gene level analysis of T cell antigen receptor (TCR) on the pathological effects of autoimmune diseases, the human TCR is 80 ~ 90K heterodimers will be disulfide bond Two glycosylated peptide chains (α, β chains) are linked, and TCR belongs to the Ig family of members. Therefore, the origin, distribution and recombination of peptide chains are similar to the latter.