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分析慢性乙型肝炎患者外周血淋巴细胞自发及丝裂霉素（ＭＭＣ）诱发ＳＣＥ的改变，并用阿糖腺苷Ａｓａ─Ａ处理血标本，观察其对ＳＣＥ变化率的影响．结果表明，慢性乙型肝炎患者的ＳＣＥ率明显高于正常人（＜０．０１），提示有ＤＮＡ损伤的存在．血标本经Ａｒａ─Ａ处理后，ＳＣＥ明显低于处理前（Ｐ＜０．０１）．本文从细胞遗传学角度为Ａｒａ—Ａ治疗慢性乙型肝炎提供了又一佐证。
The changes of spontaneous peripheral blood lymphocytes and mitomycin C (MMC) -induced SCE in patients with chronic hepatitis B were analyzed. Blood samples were treated with AsA-A and their effects on the changes of SCE were observed. The results showed that patients with chronic hepatitis B SCE rate was significantly higher than normal (<0.01), suggesting the existence of DNA damage. After the blood samples were treated with Ara-A, SCE was significantly lower than before treatment (P <0.01). This article provides further evidence for the treatment of chronic hepatitis B by Ara-A from the perspective of cytogenetics.