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目的：探讨胰岛细胞肿瘤增殖细胞核抗原（ＰＣＮＡ）表达与形态学特征的关系。方法：回顾性复习１２例胰岛细胞瘤的病理资料，并以ＳＰ法作ＰＣＮＡ免疫组化标记。结果：条索状、小梁状排列的大细胞型胰岛细胞瘤ＰＣＮＡ呈强阳性，而胰岛状、玫瑰花样排列的小细胞者ＰＣＮＡ表达弱，两者差异有显著性（Ｐ＜０．０１）。结论：ＰＣＮＡ表达程度与胰岛细胞瘤的细胞学特征有关，可以此作为判断良恶性的指标之一。
Objective: To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) and morphological features in islet cell tumor. Methods: Retrospective review of 12 cases of islet cell tumor pathological data and S P method for PCNA immunohistochemical labeling. Results: PCNA was strongly positive in large cord trabecular arranged pancreatic islet cell tumor, while PCNA expression was small in islet - like and rose - like small cells, with significant difference (P <0.01) . Conclusion: The degree of PCNA expression is related to the cytological characteristics of islet cell tumor, which can be used as one of the indicators to judge benign and malignant.