Objectives To evaluate the therapeutic effect of transcatheter Amplatzer device on the closure of ventricular septal defect (VSD).Methods Among 143 patients with VSD, 135patients with perimembrane VSD and 2 with muscular VSD aged 2.5 ～28 years old, were successfully closed with Amplatzer occluder device by the percutaneous guidwire through femoral artery-VSD-femoral vein route under the guidance of fluoroscopy, ventriculography and transthoracic echocardiography (TTE). The diameters of the VSDs were 2.3～15.7 (6.90±2.76)mm by left ventriculography. Results The success rate of transcatheter closure of VSD with Amplatzer devices was 96% (137/143). Minimal residual amount of shunts were found in one patient, although the shunts was decreased one month after the procedure. There were one patient who had respiratory arrest during the procedure, 7 patients(5%)had conduction disturbance,3 patients had complete left bundle branch block, 2patients had complete right bundle branch block, 1patient had I degree atrial-ventricular block and 1patient had Ⅲ degree atrial-ventricular block during hospitalization. The diameters of the occluder ranged from 4 to 23 (9.13±3.31)mm and were symmetrical in 122 patients and asymmetrical in 15 patients.Conclusions Transcatheter closure of the perimembranous ventricular septal defect using Amplatzer VSD occluder device is an efficient method for patients with the perimembranous VSD. The operation is simple with a high success rate and a good effect.