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中脑黑质一纹状体多巴胺(DA)神经通路变性而引起纹状体内多巴胺含量的降低,是震颤性麻痹(巴金森氏病)的主要病因。尽管由于左旋多巴,美多巴等药物的应用给本病的治疗带来希望,但廿多年来各国的临床经验证明:此类药物仅能对1/3的病人有较长期的疗效,而且90％以上的病例发生副作用。因此巴金森氏病的治疗尚未得到满意解决。端典的Bjorklund等曾在大鼠中造成一侧或双侧黑质一纹状体神经通路损
Degeneration of dopamine (DA) in the substantia nigra and striatum of the midbrain leads to a decrease in dopamine levels in the striatum and is the major cause of tremoropannula (Parkinson’s disease). Although the application of drugs such as levodopa and meduber has brought hope for the treatment of this disease, over the past 20 years of clinical experience in various countries have proved that such drugs can only have longer-term efficacy in 1/3 of patients, and More than 90% of cases have side effects. Therefore, the treatment of Parkinson’s disease has not been satisfactorily resolved. Bodorkian Djondikon et al. Have caused one or both nigrostriatal nerve pathways in rats