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选健康雄性Wistar大鼠38只,乌拉坦腹腔麻醉,制动后行人工呼吸,一侧髂总动脉直接描记血压。鼠头按Pellegrino图谱定位,将微量注射针头插入孤束核(NTS)。比较注药前后刺激迷走神经中枢端产生的加压反应。结果发现NTS内注入新斯的明及乙酰胆碱,迷走加压反应加强,注入阿托品加压反应减弱,注入六甲双胺加压反应与注药前无明显改变。证实NTS是迷走加压反应通路中的重要组成部分,乙酰胆碱是这一反应的中间递质。
Thirty-eight healthy male Wistar rats were anesthetized with urethane intraperitoneally and resuscitated with artificial resuscitation after brakes. The common iliac artery of one side was directly marked with blood pressure. The mouse head is positioned on the Pellegrino map and the microinjection needle is inserted into the nucleus of the solitary tract (NTS). Comparison of injection before and after stimulation of the vagus nerve center produced by the pressure response. The results showed that neostigmine and acetylcholine were injected into NTS. The vagal compression reaction was strengthened. The pressure response to atropine injection was weakened. There was no significant change in pressure response before administration of hexamethonium in the NTS. NTS was demonstrated to be an important part of the vagus pressor response pathway, and acetylcholine is the intermediate transmitter of this response.