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近来发现,有些下丘脑激素的类似物,可抑制内分泌依赖性肿瘤的生长,并有重要的临床价值。作者综述了近来LH-RH 激动剂及拮抗剂类似物对激素依赖性肿瘤的实验及临床研究结果,特别是对前列腺癌的治疗。前列腺癌一、LH-HR 激动剂对前列腺癌动物模型的实验研究D-色~6-LH-RH 是一超高活性(Superac-tive)长效的LH-RH 激动剂,活性较LH-RH高100倍,短期注射能增强并延长促黄体生成
Recently, it has been found that some hypothalamic hormone analogues can inhibit the growth of endocrine-dependent tumors and have important clinical value. The authors reviewed recent experimental and clinical studies of LH-RH agonists and antagonist analogues on hormone-dependent tumors, particularly for the treatment of prostate cancer. Prostate cancer I. LH-HR agonists in animal models of prostate cancer D-color~6-LH-RH is a superac-tive long-acting LH-RH agonist with higher activity than LH-RH. 100 times higher, short-term injection can enhance and prolong luteinogenesis