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胃肝样腺癌(HAS)是原发于胃黏膜且同时具有腺癌和肝细胞癌样分化特征的一种胃癌,在患者血清及肿瘤组织中可检测出甲胎蛋白(AFP)增高,1-抗胰蛋白酶(1-AAT)、1-抗糜蛋白酶(1-ACT)阳性。临床上多见于老年男性,胃窦部多发,血清AFP可不同程度升高,肝和淋巴结转移率高,分化低,预后明显较普通胃癌差。HAS临床少见,恶性程度高,预后差。本文对近年来国内外的HAS相关文献作一综述。1概述HAS多见于中老年人,平均发病年龄为63.5岁,好发生于胃窦部,占60.2%,其次为胃底及贲门[1]。以浸润溃疡型为主,约占61.7%。2组织学起源
Gastric hepatoid adenocarcinoma (HAS) is a type of gastric cancer that originates in the gastric mucosa and has both adenocarcinoma and hepatocellular carcinoma-like differentiation characteristics. Alpha-fetoprotein (AFP) elevation can be detected in the patient’s serum and tumor tissue, 1 - Anti-trypsin (1-AAT), 1-anti-chymotrypsin (1-ACT) positive. Clinically more common in older men, multiple gastric antrum, serum AFP can be increased to varying degrees, liver and lymph node metastasis rate, low differentiation, prognosis is significantly worse than ordinary gastric cancer. HAS is rare clinically, with a high degree of malignancy and poor prognosis. This article reviews recent domestic and foreign HAS related literature. 1 Overview HAS is more common in middle-aged and elderly people. The average age of onset is 63.5 years, which occurs in the antrum of the stomach, accounting for 60.2%, followed by the fundus and cardia [1]. Mainly infiltration ulcer type, accounting for about 61.7%. 2 histological origin