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本实验观察了原发性高血压(EH)病人红细胞Ca~(2+)Mg~(2+)-ATP酶活性,红细胞和血浆钙调素(CaM)的变化及哌唑嗪对其影响。结果表明:EH病人红细胞基础和最大Ca~(2+),Mg~(2+)-ATP酶活性显著下降,并与血压呈显著负相关;红细胞CaM活性也显著降低并与最大Ca~(2+),Mg~(2+)-ATP酶活性呈显著正相关;经哌唑嗪治疗后,EH病人红细胞Ca~(2+),Mg~(2+)-ATP酶活性和CaM变化不显著,但血浆CaM有所降低。提示EH病人红细胞钙代谢异常与外周阻力增高有密切关系,哌唑嗪对细胞和体液CaM有不同影响。
This experiment observed the changes of Ca2 + - Mg2 + - ATPase activity, erythrocyte and plasma CaM in erythrocytes of patients with essential hypertension (EH) and the effect of prazosin on it. The results showed that the basic and maximum Ca ~ (2 +) and Mg ~ (2 +) - ATPase activities of erythrocytes were significantly decreased in EH patients and significantly negatively correlated with blood pressure; the activity of CaM in erythrocytes was also significantly decreased, +) And Mg ~ (2 +) - ATPase activity. After prazosin treatment, the changes of Ca ~ (2 +) and Mg ~ (2 +) - ATPase activities and CaM in erythrocytes of EH patients were not significant , But plasma CaM decreased. Prompt EH patients with abnormal erythrocyte calcium metabolism and peripheral resistance is closely related to prazosin on cell and humoral CaM have different effects.