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目的观察长期吸入沙美特罗替卡松粉剂对于稳定期中重度慢性阻塞性肺疾病(COPD)患者肺功能及生活质量的影响。方法将50例COPD稳定期患者随机分为两组。治疗组长期给予沙美特罗替卡松粉剂2次/d,每次1吸;对照组仅在急性发作期吸入沙美特罗替卡松粉剂1,年后比较两组肺功能、呼吸困难指数、急性发作次数及平均入院天数。结果①治疗组一年后FEV1及FVC较对照组有明显改善;②治疗组呼吸困难明显改善;③治疗组急性发作次数及住院天数均少于对照组。结论对于稳定期中重度COPD患者长期吸入沙美特罗替卡松粉剂可改善肺功能及生活质量。
Objective To observe the effects of long-term inhaled salmeterol-tolterpine powder on pulmonary function and quality of life in patients with stable chronic obstructive pulmonary disease (COPD). Methods Fifty patients with stable COPD were randomly divided into two groups. The treatment group was given salmeterol / fluticasone powder twice a day for 1 week, while the control group was given inhaled sotalol powder only during the acute phase of exacerbation. One year later, the pulmonary function, dyspnea index, The number of acute attacks and average number of days of admission. Results ① The FEV1 and FVC of the treatment group were significantly improved after one year as compared with the control group. ② The dyspnea of the treatment group was significantly improved. ③ The number of acute attacks and days of hospitalization in the treatment group were less than those in the control group. Conclusions Long-term inhaled salmeterol / fluticasone powder may improve pulmonary function and quality of life in patients with stable COPD.