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目的探讨三维适形放疗联合经导管肝动脉化疗栓塞治疗原发性肝癌的临床疗效。方法随机将2008年11月至2011年11月住院治疗的130例原发性肝癌患者分为对照组和观察组,每组各65例。对照组患者行经导管肝动脉化疗栓塞治疗,观察组患者在三维适形放疗后再行经导管肝动脉化疗栓塞治疗,比较两组患者临床疗效和药物不良反应情况。结果观察组患者总有效率(78.5%)明显高于对照组的(61.5%),差异有统计学意义(P<0.05);而对照组和观察组不良反应发生率差异无统计学意义(P>0.05)。结论三维适形放疗联合经导管肝动脉化疗栓塞治疗原发性肝癌疗效确切,安全高效,不良反应少。
Objective To investigate the clinical efficacy of three-dimensional conformal radiotherapy combined with transcatheter hepatic arterial chemoembolization in the treatment of primary liver cancer. Methods A total of 130 patients with primary liver cancer hospitalized from November 2008 to November 2011 were randomly divided into control group and observation group with 65 cases in each group. Patients in the control group underwent transcatheter arterial chemoembolization. Patients in the observation group received transcatheter hepatic arterial chemoembolization after three-dimensional conformal radiotherapy. Clinical efficacy and adverse drug reactions were compared between the two groups. Results The total effective rate (78.5%) in the observation group was significantly higher than that in the control group (61.5%) (P <0.05), while there was no significant difference in the incidence of adverse reactions between the control group and the observation group (P > 0.05). Conclusion Three-dimensional conformal radiotherapy combined with transcatheter hepatic arterial chemoembolization for the treatment of primary hepatocellular carcinoma is effective, safe and effective with few adverse reactions.