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半胱氨酸蛋白酶通过对细胞外基质和基底膜的降解而促进肿瘤浸润转移,其在头颈部恶性肿瘤浸润转移过程中起重要作用,其可望成为头颈部恶性肿瘤预后的肿瘤标记物。本文就半胱氨酸蛋白酶的一般特性、家族、抑制剂及其可能作用机制作一综述。
Cysteine protease promotes tumor invasion and metastasis through the degradation of extracellular matrix and basement membrane, which plays an important role in the invasion and metastasis of head and neck malignant tumors, which is expected to become a tumor marker for the prognosis of head and neck malignant tumors . This article reviews the general characteristics of cysteine proteases, families, inhibitors and their possible mechanism of action.