心肌梗死是指冠状动脉严重狭窄，导致冠状动脉血管持续完全闭塞，引起心肌坏死，其中90%的患者行冠脉造影时可见冠状动脉狭窄(>50%)或阻塞，但仍有10%的患者未见明显狭窄，即非阻塞性心肌梗死(MINOCA)。MINOCA发病率为6%左右，呈逐年上升趋势，患者平均年龄约为55岁，其中女性占40%。其病因复杂，起病急，临床表现复杂多变，主要心血管不良事件(MACE)的发生率很高，一年内死亡率高达3.5%，目前并没有统一的诊治方案。本文就近几年MINOCA的病因及诊疗的研究进展做一综述。“,”Myocardial infarction refers to severe coronary artery stenosis, which leads to continuous and complete occlusion of coronary artery and myocardial necrosis. Coronary artery stenosis (>50%) or occlusion can be seen in 90% of patients undergoing coronary angiography, but 10% of patients have no obvious stenosis, that is, non obstructive myocardial infarction (MINOCA). The incidence rate of MINOCA was about 6%, showing an upward trend year by year, with an average age of 55 years, of which 40% of women. Its etiology is complex, the onset is urgent, and the clinical manifestations are complex and changeable. The incidence of major adverse cardiovascular events (MACE) is very high, and the mortality rate within one year is as high as 3.5%. There is no unified diagnosis and treatment plan at present. In this paper, the etiology, diagnosis and treatment of MINOCA were reviewed.