论文部分内容阅读
目的比较三种常用催眠药在特定环境下的快速催眠效果及后遗效应，为飞行员用药研究提供参考。方法在模拟歼－６飞机噪声干扰环境中（１５０Ｈｚ、９５ｄＢ）观察速可眠（ＳＥＣ）、三唑仑（ＴＺＬ）、褪黑素（ＭＬＴ）对８名健康男性（１８～２０岁）多导睡眠图（ＰＳＧ）指标的影响，并对其催眠质量、后遗效应、作业效率作主、客观评定。结果ＳＥＣ、ＴＺＬ均以减少觉醒时间（ＡＴ），缩短睡眠潜伏期（ＳＬ）和快速眼动睡眠潜伏期（ＲＥＭＬ），增加实际睡眠时间（ＡＳＴ）来提高催眠效率（ＥＦＦ），ＭＬＴ对上述各指标影响不显著（Ｐ＞０．０５）。ＳＥＣ、ＴＺＬ的ＥＦＦ分别为（９４．４５±２．３３）％、８５．３５％±２．１５％，接近基础生理组（９６．６５±１．５５）％，ＭＬＴ的ＥＦＦ为（７０．０５±２．１３）％，接近安慰剂组。ＴＺＬ的催眠诱导时间［ＳＬ＝（６．１５±２．５５）ｍｉｎ］比ＳＥＣ［ＳＬ＝（８．７５±３．３７）ｍｉｎ］和ＭＬＴ［ＳＬ＝（１５．８４±７．３５）ｍｉｎ］的短，并显著低于基础生理值［ＳＬ＝（１１．５８±６．３２）ｍｉｎ］。催眠质量主观评定与ＰＳＧ检查结果基本一致。复杂任务操作中，ＳＥＣ、ＴＺＬ组的反应时（ＲＴ）与基础组无显著性差异?
Objective To compare the rapid hypnotic effects and the effects of three hypnotic drugs hypnosis hypnosis in a specific environment, provide a reference for pilot study. Methods A total of 8 healthy male (18-20 years old) multi-conductors were enrolled in this study. The effects of SEC, triazolam (TZL) and melatonin (MLT) Sleep chart (PSG) indicators, and its quality of hypnosis, after effects, operating efficiency and objective assessment. Results Both SEC and TZL improved the hypnotic efficiency (EFF) by decreasing the awakening time (AT), shortening the sleep latency (SL) and REM sleep latency (REM) and increasing the actual sleep time (AST) Not significant (P> 0.05). The EFFs of SEC and TZL were (94.45 ± 2.33)% and 85.35% ± 2.15%, respectively, which were close to the basal physiological group (96.65 ± 1.55)% and the EFF of MLT was (70. 05 ± 2.13)%, close to the placebo group. The hypnotic induction time of TZL was significantly higher than that of SEC (SL = (8.75 ± 3.37) min vs MLT [SL = (6.15 ± 2.55) min vs SEC ], And significantly lower than the basic physiological value [SL = (11.58 ± 6.32) min]. Subjective assessment of hypnosis quality and PSG test results are basically the same. In the complex task operation, there was no significant difference between the response time (RT) of SEC and TZL group and the basic group.