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目的了解非瓣膜病心房颤动(房颤)患者血小板的活化状态。方法观察92例非瓣膜病持续性房颤患者(房颤组)与60例窦性心律者(对照组)血小板功能状态的分子标记物水平,用酶联免疫吸附双抗体夹心法测定血浆血小板α颗粒膜糖蛋白-140(GMP-140)水平,用放射免疫分析法测定血栓素B2(TXB2)和6-酮-前列腺素F1α(6-k-PGF1α)水平。结果房颤组GMP-140和TXB2水平显著高于对照组,6-k-PGF1α水平显著低于对照组,TXB2/6-k-PGF1α比值也显著高于对照组。调整其他影响因素后,房颤组GMP-140和TXB2水平仍显著高于对照组,6-k-PGF1α水平仍显著低于对照组。GMP-140水平在合并糖尿病和合并高甘油三酯血症的房颤患者进一步升高。结论非瓣膜病房颤患者处于血小板激活状态。
Objective To understand the activation of platelets in patients with nonvalvular atrial fibrillation (AF). Methods 92 patients with nonvalvular atrial fibrillation patients with atrial fibrillation and 60 patients with sinus rhythm (control group) platelet function status of molecular markers, using enzyme-linked immunosorbent assay with double antibody sandwich method of plasma platelet α Granulocyte glycoprotein-140 (GMP-140) levels were determined by radioimmunoassay. The levels of TXB2 and 6-keto-PGF1α were measured by radioimmunoassay. Results The levels of GMP-140 and TXB2 in atrial fibrillation group were significantly higher than those in control group, the level of 6-k-PGF1α was significantly lower than that in control group, and the ratio of TXB2 / 6-k-PGF1α was also significantly higher than that in control group. After adjustment for other factors, the levels of GMP-140 and TXB2 in AF group were still significantly higher than those in control group, and the level of 6-k-PGF1α was still significantly lower than that in control group. The level of GMP-140 is further elevated in patients with atrial fibrillation associated with diabetes mellitus and hypertriglyceridemia. Conclusions Patients with nonvalvular atrial fibrillation are in platelet activation status.