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从人绒毛膜促性腺激素（hCG）中分离β亚单位（βhCG），用异质双功能交联剂SPDP将βhCG与破伤风类毒素偶联，形成生物大分子抗原，脂质体包被后制成hCG避孕疫苗。按生物制品规程要求检定，安全试验合格。用此疫苗免疫小白鼠和恒河猴，小白鼠免后21天的血清抗体可中和22ng／mlβhCG，其抗体峰在免后35天。猴的抗体峰在免后60天（112．3ng／ml）。恒河猴在10个月之后接种第2针，其抗体峰值为90ng／ml。
Β subunit (βhCG) was isolated from human chorionic gonadotropin (hCG), and βhCG was coupled with tetanus toxoid with heterogeneous bifunctional cross-linker SPDP to form biomacromolecule antigen. After liposome coating Made hCG contraceptive vaccine. Accreditation requirements of biological products, safety test pass. Immunization of mice and rhesus monkeys with this vaccine, serum antibodies 21 days after immunization can neutralize 22ng / ml βhCG, the antibody peak in 35 days after immunization. The monkey antibody peak was 60 days after immunization (112.3 ng / ml). Rhesus monkeys inoculated with a second needle after 10 months had an antibody peak of 90 ng / ml.