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复方氯霉素洗剂含氯霉素1％,水杨酸2％,具有止痒,杀菌,消炎作用,中国医院制剂规范中用亚硝酸钠法测定氯霉素的含量,用中和法测定水杨酸的含量,操作较繁烦,且易产生误差,本文采用双波长分光光度新计算法,直接测定两组份的含量,获得满意结果。 基本原理:在选定两个波长λ_1,λ_2处测定混合溶液,待测组分和干扰组分的吸收度值分别以A_1~S、A_2~S及A_1~R、A_2~R表示,由于干扰组分的影响,在这两个波长所测得的吸收度值A_1、A_2是二者的混合吸收度值,根据双波长测定依据A_1~R:A_2~R,则△A=A_1-A_2=A_1-A_2-(A_1~R-A_2~R)=A_1~S-A_2~S
Compound chloramphenicol lotion containing chloramphenicol 1%, 2% salicylic acid, with anti-itch, bactericidal, anti-inflammatory effect, Chinese hospital preparation norms sodium nitrite method for the determination of chloramphenicol content, determination by the neutralization method Salicylic acid content, the operation is more troublesome, and easy to produce error, this paper uses a new double-wavelength spectrophotometry, direct determination of the content of the two components to obtain satisfactory results. Rationale: The mixed solution is measured at two selected wavelengths, λ_1 and λ_2. The absorbance values of the components to be measured and the interfering components are expressed as A_1 ~ S, A_2 ~ S and A_1 ~ R, A_2 ~ R, respectively. A_1, A_2, R_2, R_2, R_A_2, R_A_2, R_A_2, R_A_2, R_A_2, A_1-A_2- (A_1-R-A_2-R) = A_1-S-A_2-S