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随着抗生素的广泛使用,淋病奈瑟菌对常用的抗生素产生了不同程度的耐药。现综述近年淋病奈瑟菌的耐药性及耐药基因的研究进展,包括:改变PBPs的胞内作用靶位,导致对青霉素类抗生素的耐药,gyrA基因、parC基因和norm基因的突变,导致对氟喹诺酮类抗生素的耐药,药物外排机制引起多重抗生素的通透性降低,teM-1基因和tetM基因编码的胞质蛋白抑制了四环素类药物对细菌的毒性作用,阿奇霉素和大观霉素耐药与作用靶位的改变等。
With the widespread use of antibiotics, Neisseria gonorrhoeae have produced varying degrees of resistance to commonly used antibiotics. The progress of drug resistance and drug resistance genes of Neisseria gonorrhoeae in recent years are reviewed, including: changing the intracellular targets of PBPs, leading to the resistance to penicillin antibiotics, the mutation of gyrA gene, parC gene and norm gene, Leading to resistance to fluoroquinolones, drug efflux mechanism caused by multiple antibiotic permeability decreased, the cytoplasmic protein encoded by the teM-1 gene and the tetM gene inhibited the toxic effects of tetracyclines on bacteria, azithromycin Su-resistance and the role of target changes.