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目的：了解张家港市乙肝病毒（以下简称HBV）感染者感染状态和进展情况，为制订HBV感染者管理方案提供参考依据。方法对张家港市2009～2010年乙肝流行病学调查发现的1910例HBV感染者，开展问卷调查，采集静脉血，进行乙肝血清学检测。结果 HBV感染人群 HBsAg阳性率为90.57%，HBeAg阳性率为6.65%，抗-HBe阳性率为81.40%。不同HBV-M组合模式的ALT升高率有显著性差异。男女HBeAg阳性率分别为7.27%和7.42%，抗-HBe阳性率分别为83.85%和85.85%，两者均无显著性差异。有明确免疫史人群HBsAg阳性率明显低于未免疫人群，且差异具有统计学意义。结论对HBV感染人群要进行定期随访，及时了解感染进展情况，阻止乙肝病毒传播和病情恶化。“,”Objective To understand the infectious state and progress of the patients with hepatitis B virus (HBV), and to of er the reference for working out a management scheme for patients with HBV. Methods The questionnaire survey was carried out among a population of 1910 patients with HBV, who are identified in the investigation of the hepatitis B epidemiology in Zhangjiagang from 2009 to 2010. The venous blood was col ected and subject to the hepatitis serological tests. Results The positive rate of the HBsAg in the patients with HBV is 90.57%, while that of the HBeAg and Anti-HBe are 6.65%and 81.40%, respectively. Significant distinction is visible among the rising rate of the ALT of various HBV-M composite modes. The positive rate of HBeAg in male and female are 7.27%and 7.42%, whereas the Anti-HBe positive rate are 83.85%and 85.85%, respectively, and both of them show slight dif erence. Comparing to the unimmunized individuals, decline of the HBsAg positive rate in the populations with identified immune history is obvious, and the distinction plays a crucial role in statistics. Conclusion It is necessary to fol ow up the patients with HBV regularly, to acquire information on the infection progress timely, and to prevent the spread of the HBV and deteriorating of the disease.