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[目的]了解延边地区医院门诊、住院人群HCV感染状况。[方法]应用酶联免疫法检测21291例样本血清中HCV抗体;对HCV抗体阳性者,检测其血清中HCV RNA及肝功能,并进行流行病学史调查。[结果]21291例样本中HCV感染率为4.78%;男性感染率为3.76%,低于女性6.03%(P﹤0.05)。HCV抗体阳性者肝功能及相关生化指标56.67%在异常范围;HCV RNA阳性率为77.33%;HCV感染者中有输血史、手术史者比例较高。[结论]HCV感染率女性高于男性;其感染除与易感因素有关外,大多为不能诉述易感因素的“不明原因”感染。HCV抗体阳性者大多无症状,肝功能及相关生化指标多异常。
[Objective] To understand the prevalence of HCV infection in hospital outpatients and inpatients in Yanbian area. [Methods] Serum HCV antibodies were detected by enzyme-linked immunosorbent assay (ELISA) in 21 291 samples. Serum HCV RNA and liver function were detected in HCV antibody-positive patients and the epidemiological history was also investigated. [Results] The HCV infection rate in 21291 cases was 4.78%. The infection rate in males was 3.76%, lower than that in females 6.03% (P <0.05). HCV antibody-positive liver function and related biochemical indicators 56.67% in the anomaly range; HCV RNA positive rate was 77.33%; HCV infection in blood transfusion history, a higher proportion of surgical history. [Conclusion] The prevalence of HCV in women is higher than that in men. The infection is mostly related to the “unexplained” infection which can not be referred to the predisposing factors except for the susceptibility factors. HCV antibody-positive mostly asymptomatic, abnormal liver function and related biochemical indicators.