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药物热是由于使用某种药物而直接或间接引起的发热。是药物的副作用之一,约占3～5％。如不能及时识别治疗,可危及生命。 一、药物热的发病机理和临床类型 关于发热的发病机理近代研究证明是由于不同的外源性致热原(毒性的、免疫性的、感染性的)进入机体后,首先被网状内皮系统的吞噬细咆昕吞噬,同时释放出一种具有致热作用的内源性致热原(即白细胞性致热原),作用于视丘下部的体温调节中枢,使新陈代谢增加但散热减慢。白细胞性致热原对热敏神经原和冷敏神经原有特异性的选择作用。它可使热敏神经原受到抑制,而降低散热反应;同时又使冷敏神经原产生兴奋而继续产热反应。由于这种双重作用而导致了体温的异常增高。
Drug fever is caused by the use of a drug that directly or indirectly causes fever. Is one of the side effects of drugs, accounting for about 3 to 5%. Failure to identify treatment promptly can endanger life. First, the pathogenesis and clinical types of drug fever on the pathogenesis of fever Modern research proved that due to different exogenous pyrogens (toxic, immune, infectious) into the body, first by the reticuloendothelial system The phagocytosis of phagocytosis by phagocytosis results in the release of a pyrogenic endogenous pyrogen (ie, a leukocyte pyrogen) that acts on the thermoregulatory center of the hypothalamus, increasing metabolism and slowing down heat loss. Selective effects of leukocyte pyrogens on the specificity of heat-sensitive and cold-sensitive neurons. It causes the heat-sensitive neurons to be restrained, which reduces the heat-dissipation reaction, while at the same time it makes the cold-sensitive neurons excited and continues to produce heat. Due to this dual effect, an abnormal increase in body temperature was caused.