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目的:研究神龙脉通口服液对麻醉犬脑血流量和脑血管阻力的影响。方法:将30只犬随机分为空白对照组、神龙脉通低、中、高剂量组、尼莫地平组,十二指肠给药,用电磁流量计和生物医学信号采集处理系统检测颈总动脉血流量和动脉血压,分别于给药后10,20,30,60,90,120 min记录各指标并计算脑血流量和脑血管阻力。结果:神龙脉通口服液高、中、低剂量(1.97,3.94,7.88g·kg~(-1))及尼莫地平片(3.2mg·kg~(-1))均能显著增加麻醉犬的脑血流量(P<0.05,神龙脉通口服液高、中、低剂量自30 min开始起效,持续至120 min,尼莫地平片自30 min开始起效,持续至90 min)、降低脑血管阻力(P<0.05,神龙脉通口服液高、中剂量及尼莫地平片自30 min开始起效,持续至120 min,神龙脉通低剂量自30 min开始起效,持续至98min)。结论:神龙脉通口服液可通过增加脑血流量、降低脑血管阻力,改善脑血液循环。
Objective: To study the effect of Shenlongmaitong Oral Liquid on cerebral blood flow and cerebral vascular resistance in anesthetized dogs. Methods: Thirty dogs were randomly divided into control group, Shenlongmai low, middle and high dose group, nimodipine group and duodenum. Electrocardiograph and biomedical signal acquisition system were used to detect total neck Arterial blood flow and arterial blood pressure were recorded at 10,20,30,60,90,120 min after administration of each index and calculate cerebral blood flow and cerebral vascular resistance. Results: Shenlongmaitong oral liquid could significantly increase anesthesia in high, medium and low doses (1.97, 3.94, 7.88g · kg -1) and nimodipine (3.2mg · kg -1) (P <0.05, high, medium and low doses of Shenlongmaitong Oral Liquid began to take effect from 30min to 120min, and nimodipine began to take effect from 30min to 90min) and decreased Cerebrovascular resistance (P <0.05, Shenlongmaitong Oral Liquid high, medium dose and nimodipine tablets from 30min onset, continued to 120min, Shenlongmantong low dose from 30min onset, lasting to 98min) . Conclusion: Shenlongmaitong oral liquid can improve cerebral blood circulation by increasing cerebral blood flow, reducing cerebral vascular resistance.