【摘 要】
：
Dear Editor,RNA knockdown in vivo carries significant potential for disease modeling and therapies.Despite the emerging approaches of CRISPR/Cas9-mediated perma
【机 构】
：
Institute of Neuroscience, State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiolo
论文部分内容阅读
Dear Editor,RNA knockdown in vivo carries significant potential for disease modeling and therapies.Despite the emerging approaches of CRISPR/Cas9-mediated permanent knock out of targeted genes, strategies targeting RNA for disruption are advantageous in the treatment of acquired metabolic disorders when permanent modification of genome DNA is not appropriate, and RNA virus infection diseases when pathogenic DNA is not available (such as SARS-Cov-2 andMERS infections).
其他文献
Sry-related high-mobility box 2 (SOX2) is a critical transcription factor that plays an important role in various phases of embryonic development and maintenanc
Oxygen is vital for most living organisms.During the course of evolution, animals have developed a highly conserved and elegant pathway to regulate oxygen sensi
人类在地球上已经生活了几万年.rn现在,人们正兴高采烈地做着21世纪的梦,议论着如何继续主宰这个地球.rn人类以自己的智慧和伟大的创造力改造了地球.在这个美丽星球上,几乎没
关于新业务排行榜,我们一贯秉承独立、客观、公正的原则来报告各大代理商在亚太区市场中的业务得失情况,并在年底时发送给各个代理商集团领导层进行分享,得到业界的普遍认同
前段时间，一本“可以喝的书”红遍了微信朋友圈，据说这本书可以解决地球上超过6亿人的饮用水问题，诸多媒体也纷纷为之点赞。微信文章声称，这本书的使用方法非常简单，只要撕下一张
Dear Editor,African swine fever (ASF) is a highly contagious disease of domestic pigs caused by African swine fever virus (ASFV),with mortality rates approachin
In this issue of the Protein & Cell Joual, a research team (from Institute of Biophysics, Chinese Academy of Sciences) led by professors Xiangxi Wang and Zihe R
Dear Editor,Plant-specific WRKY transcription factors (TFs) are among the largest families of TFs in higher plants;they are also found in the unicellular eukary
Dear Editor,DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing,gene im
清代的大理与中原地区一样有过“康乾盛世”,政治统一,经济发展,文化繁荣,人丁兴旺。但后期,政治腐败,经济衰败,发生了以回族领袖杜文秀为首的农民大起义。被镇压后,人口锐减