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目的:研究海洋真菌多糖YCP对动物抑瘤作用和免疫功能的调节作用,探讨其抗肿瘤作用的机理。方法:采用抗移植性肿瘤实验方法,检测受试药物对荷瘤小鼠的瘤重及体重的影响。以荷瘤小鼠的血清半数溶血值(HC50)及吞噬指数K及吞噬系数α值等为指标,观察药物对免疫功能的影响。结果:与空白对照组相比,YCP(9,3 mg/kg,ivi、p)对小鼠移植瘤肝癌实体型(Heps)、肉瘤180(S180)、Lewis肺癌的肿瘤生长具有明显的抑制作用(P<0.01),且对小鼠的体重无明显的抑制作用。YCP(9,3 mg/kg)可显著提高S180荷瘤小鼠的吞噬指数k和血清半数溶血值(P<0.01,P<0.05)。结论:YCP具有明显的抗肿瘤活性和显著提高S180荷瘤小鼠免疫功能的作用。
OBJECTIVE: To study the regulatory effect of marine fungal polysaccharide YCP on tumor inhibition and immune function and to explore the mechanism of its anti-tumor effect. Methods: The anti-transplant tumor experiment method was used to test the effect of test drugs on the tumor weight and body weight of tumor-bearing mice. The effects of drugs on immune function were observed with the half-value of serum hemolytic value (HC50), phagocytic index (K) and phagocytic coefficient (α) of tumor-bearing mice. Results: Compared with the blank control group, YCP (9,3 mg / kg, ivi, p) significantly inhibited the tumor growth of HepG mice, S180 and Lewis lung carcinomas. (P <0.01), and no significant inhibition of body weight in mice. YCP (9,3 mg / kg) significantly increased the phagocytic index (k) and serum hemolytic value of S180 tumor-bearing mice (P <0.01, P <0.05). Conclusion: YCP has obvious anti-tumor activity and significantly enhances the immune function of S180 tumor-bearing mice.