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目的:探讨口腔鳞状细胞癌(OSCC)和白斑(LK)患者人乳头瘤病毒16型(HPV-16)感染和临床病理参数之间的相关性。方法:收集30例OSCC和5例LK患者的组织切片,所有病例均经病理学确诊,提取组织DNA,通过巢式PCR检测HPV-16感染情况。结果:HPV-16与TNM分级之间未见相关性,60岁以下女性患者的HPV-16感染率高于60岁以上女性患者(P=0.024),而男性患者未见HPV-16感染和年龄存在相关性(P=0.649)。结论:60岁以下女性OSCC及LK患者中出现较高的HPV-16感染率,提示这可能是新的致癌危险因子。
Objective: To investigate the correlation between HPV-16 infection and clinicopathological parameters in patients with oral squamous cell carcinoma (OSCC) and leukoplakia (LK). Methods: Tissue sections of 30 patients with OSCC and 5 patients with LK were collected. All cases were pathologically diagnosed, and tissue DNA was extracted. HPV-16 infection was detected by nested PCR. Results: No correlation was found between HPV-16 and TNM grade. The prevalence of HPV-16 in women under 60 years old was higher than that in women over 60 years old (P = 0.024), but no HPV-16 infection and age There was a correlation (P = 0.649). CONCLUSIONS: The high prevalence of HPV-16 infection in OSCC and LK in women under 60 years of age suggests that this may be a new carcinogenic risk factor.