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目的分析在老年高血压患者中应用厄贝沙坦时辰化用药控制的效果。方法 40例老年高血压患者参与研究,对所有患者实施厄贝沙坦时辰化用药控制,分析治疗结果。结果 40例患者治疗后24小时收缩压(24 hSBP)、24小时舒张压(24 hDBP)、白昼收缩压(dSBP)、白昼舒张压(d DBP)、夜间收缩压(n SBP)、夜间舒张压(nDBP)、血压晨峰(MBPS)[(127.1±6.4)、(66.8±4.2)、(129.5±6.1)、(70.5±4.2)、(126.3±5.1)、(65.2±3.3)、(31.3±2.3)mm Hg(1 mm Hg=0.133 kPa)]均明显低于治疗前[(151.5±7.5)、(76.8±5.5)、(154.6±8.7)、(78.0±6.7)、(142.3±5.6)、(71.5±5.7)、(39.8±3.1)mm Hg],比较差异均有统计学意义(P<0.05)。40例患者治疗后全部正常R-R间期的标准差(SDNN)、24 h内连续5 min节段平均正常R-R间期的标准差(SDANN)、24 h内连续5 min节段正常R-R间期标准差的平均数(SDNNi)、连续正常R-R间期标准差的均方根(rMSSD)、两个相邻R-R间期标准差超过50 ms的心搏数在所分析信息间期内心搏数中所占比例(PNN50)[(105.5±30.5)、(92.5±21.8)、(71.7±18.1)、(36.6±15.4)、(11.4±6.9)ms]均明显高于治疗前[(81.4±18.6)、(76.4±17.5)、(57.3±17.7)、(27.3±12.0)、(7.0±4.7)ms],比较差异均有统计学意义(P<0.05)。结论厄贝沙坦时辰化用药控制用于老年高血压患者中能够有效降低血压晨峰,改善心率变异性,值得推广。
Objective To analyze the effect of irbesartan time-of-use control in elderly hypertensive patients. Methods 40 cases of elderly hypertensive patients involved in the study, the implementation of irbesartan in all patients with time-based drug control, analysis of treatment results. Results After 24 hours of treatment, systolic blood pressure (24 hSBP), 24 h DBP, dSBP, d DBP, n SBP, nocturnal diastolic pressure (nDBP) and MBPS [(127.1 ± 6.4), (66.8 ± 4.2), (129.5 ± 6.1), (70.5 ± 4.2), (126.3 ± 5.1), (65.2 ± 3.3) and (31.3 ± 2.3 mm Hg (1 mm Hg = 0.133 kPa)] were significantly lower than those before treatment [(151.5 ± 7.5), (76.8 ± 5.5), (154.6 ± 8.7), (78.0 ± 6.7), (142.3 ± 5.6) (71.5 ± 5.7) and (39.8 ± 3.1) mm Hg, respectively, with statistical significance (P <0.05). The standard deviation (SDNN) of all normal RR intervals, the standard deviation of average normal RR interval (SDANN), the average normal RR interval of 5 min in 24 h, the normal RR interval of 5 min in 24 h (SDNNi), rmsSD for standard deviation of continuous normal RR intervals, and the number of beats with standard deviations of more than 50 ms between two adjacent RR intervals (PNN50) [(105.5 ± 30.5), (92.5 ± 21.8), (71.7 ± 18.1), (36.6 ± 15.4), (11.4 ± 6.9) ms] were significantly higher than those before treatment [(81.4 ± 18.6) (76.4 ± 17.5), (57.3 ± 17.7), (27.3 ± 12.0) and (7.0 ± 4.7) ms, respectively, with statistical significance (P <0.05). Conclusion Time-dependent administration of irbesartan in elderly hypertensive patients can effectively reduce the blood pressure morning peak, improve heart rate variability, it is worth promoting.