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目的:采用微柱凝胶技术检测孕妇血清IgG抗-A(B)血型抗体,为新生儿溶血病(HDN)的早期诊断和预防提供依据。方法:用微柱凝胶法检测在濮阳市妇幼保健院产科门诊建卡的孕妇IgG抗-A(B)效价,并追踪HDN的发生情况,分析二者的相关性。结果:2 592例受检O型血孕妇中,血清IgG抗-A(B)效价≤1∶128者1 433例,出生后可疑HDN 15例,HDN 5例,发生率为1.05%;血清IgG抗-A(B)效价为1∶256~1∶512者908例,HDN 27例,发生率为2.97%;血清IgG抗-A(B)效价≥1∶1 024者251例,HDN 41例,发生率为16.3%。孕妇IgG抗-A(B)不同效价组间HDN的发生率比较差异均有统计学意义(P<0.05)。结论:随着孕妇血清IgG抗-A(B)效价的提高,HDN的发病率也增高。
OBJECTIVE: To detect IgG anti-A (B) blood group antibody in pregnant women by using microcolumn gel technique to provide basis for early diagnosis and prevention of neonatal hemolytic disease (HDN). Methods: The microcolumn gel method was used to detect IgG anti-A (B) titer of pregnant women in obstetrics and gynecology clinics in Puyang City. The incidence of HDN was followed up and the correlation between them was analyzed. Results: Among 2 592 pregnant women with O blood test, the serum IgG anti-A (B) titer was less than 1: 128 in 1 433 cases, 15 cases of suspected HDN after birth and 5 cases of HDN, the incidence rate was 1.05% There were 908 cases of IgG anti-A (B) titer of 1:256 ~ 1: 512 and 27 cases of HDN, the incidence rate was 2.97%. The serum anti-A (B) HDN 41 cases, the incidence was 16.3%. The incidence of HDN among pregnant women with different anti-A (B) titers was statistically significant (P <0.05). Conclusions: The incidence of HDN is also increased with the increase of serum IgG anti-A (B) titer in pregnant women.