论文部分内容阅读
目的:探讨炎症因子在儿童支原体肺炎中的变化,为儿童支原体肺炎的治疗提供理论依据。方法:选取2015年5月-2016年5月在医院接受治疗的90例支原体肺炎患儿作为观察组,给予其治疗,选取同期的健康儿童90名为对照组,采集两组的血清标本,使用ELISA法检测两组血清,分析比较两组白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)变化情况。结果:观察组治疗前IL-6、IL-8、IL-10、TNF-α水平明显要高于对照组,组间比较差异明显,具有统计学意义(P<0.05);治疗后,观察组IL-6、IL-8、IL-10、TNF-α水平相比于治疗前明显改善,比较差异明显,具有统计学意义(P<0.05);与对照组比较差异不明显,无统计学意义(P>0.05)。结论:炎症因子与儿童支原体肺炎产生的病理变化有着极其重要的联系,能够直接反应支原体感染及恢复的情况,其水平的高低能用来为诊断、治疗、判断支原体肺炎的病况提供依据。
Objective: To investigate the changes of inflammatory cytokines in children with mycoplasma pneumonia and to provide a theoretical basis for the treatment of children with mycoplasma pneumonia. Methods: Ninety children with mycoplasmal pneumonia who were treated in the hospital from May 2015 to May 2016 were selected as the observation group and 90 healthy children were selected as the control group. Two groups of serum samples were collected and used The levels of serum IL-6, IL-10, IL-8 and TNF-α TNF-α) changes. Results: The levels of IL-6, IL-8, IL-10 and TNF-α in the observation group before treatment were significantly higher than those in the control group, with significant difference between the two groups (P <0.05) Compared with the control group, the levels of IL-6, IL-8, IL-10 and TNF-α were significantly improved (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: Inflammatory factors play an important role in the pathological changes of children with mycoplasma pneumonia. They can directly reflect the situation of mycoplasma infection and recovery. The level of inflammatory cytokines can be used for diagnosis, treatment and judgment of mycoplasma pneumonia.