天然杀伤(NK)细胞可在体外杀伤恶性肿瘤细胞及一些表达胚胎特征的正常细胞。如果这种情况发生在个体发育早期,那将构成有损胎儿的一种危险。幸而,新生期及妊娠动物的NK细胞活性水平是低下的,但其原因尚不清楚,可能与新生及妊娠期动物有较高水平的血清甲胎蛋白(AFP),从而抑制了免疫反应有关。作者报道了纯化的小鼠胚胎来源的AFP对CBA/J小鼠脾细 Natural killer (NK) cells can kill malignant cells in vitro and some normal cells that express embryonic features. If this happens in the early stages of development, it will pose a risk to the fetus. Fortunately, the level of NK cell activity in neonatal and pregnancy animals is low, but the reason for this is unclear. It may be related to the higher level of serum alpha-fetoprotein (AFP) in newborn and gestational animals, thus inhibiting the immune response. The authors reported purified mouse embryo-derived AFP against splenocytes of CBA / J mice