论文部分内容阅读
一氧化氮作为一种气体性的信使分子在神经系统中参与神经细胞间的信息传递，对脑发育、学习和记忆等具有重要作用。本文研究了膳食锌缺乏对发育鼠小脑，纹状体和下丘脑中的一氧化氮合成酶（ＮＯＳ）活性和ｃＧＭＰ水平的影响，结果表明：小脑、纹状体和下丘脑中的ＮＯＳ活性和ｃＧＭＰ水平均呈发育性增高的趋势。各年龄段锌缺乏鼠小脑、纹状体和下丘脑ＮＯＳ活性均显著低于正常对照组；２１和３０日龄缺锌组仔鼠小脑、纹状体和下丘脑中的ｃＧＭＰ水平明显低于自由喂养组，锌缺乏时ＮＭＤＡ受体－ＮＯ－ｃＧＭＰ通路受损可能是锌缺乏影响脑发育和功能的一个重要机制。
Nitric oxide, as a gaseous messenger, participates in the information transmission between nerve cells in the nervous system and plays an important role in brain development, learning and memory. This study investigated the effects of dietary zinc deficiency on nitric oxide synthase (NOS) activity and cGMP levels in the cerebellum, striatum and hypothalamus of developing mice. The results showed that NOS activity in cerebellum, striatum and hypothalamus and cGMP levels showed a trend of increased development. The activity of NOS in cerebellum, striatum and hypothalamus of zinc deficient rats of all ages were significantly lower than that of the normal control group. The levels of cGMP in the cerebellum, striatum and hypothalamus of the zinc deficient rats at 21 and 30 days were significantly lower than that of the free Feeding groups, impaired NMDA receptor-NO-cGMP pathway during zinc deficiency, may be an important mechanism by which zinc deficiency affects brain development and function.