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近年来,针对肿瘤代谢的研究已经成为肿瘤研究的新热点,而对代谢过程中关键调控因子的研究更是肿瘤代谢研究的重中之重,转录辅激活因子过氧化物酶体增殖物激活受体γ辅激活因子1α(peroxisome proliferators activated receptor gamma co-activator 1 alpha,PGC-1α)便是其中之一。PGC-1α是线粒体生物合成的关键调控因子,其在多种代谢性疾病中扮演着重要的角色,是氧化代谢和合成代谢的关键节点,参与了肿瘤代谢的调节,可以从氧化代谢和合成代谢两个方面调控肿瘤细胞的存活、增殖和迁移。本文对PGC-1α的结构及其相关转录因子进行了综述,探讨PGC-1α通过代谢调节肿瘤发生和发展的机制,并重点阐述了PGC-1α在肿瘤代谢研究中的进展,以期为后续以PGC-1α为靶标的抗肿瘤代谢的基础研究及药物研发提供新的理论参考。
In recent years, the study of tumor metabolism has become a new focus of cancer research, and the key regulatory factors in the metabolic process is more important in the study of tumor metabolism, transcriptional coactivator peroxisome proliferator-activated receptor One of them is peroxisome proliferators activated receptor gamma co-activator 1 alpha (PGC-1α). PGC-1α is a key regulator of mitochondrial biosynthesis. It plays an important role in many metabolic diseases. It is a key node of oxidative metabolism and anabolic metabolism. It participates in the regulation of tumor metabolism, and can be selected from the aspects of oxidative metabolism and anabolism Two aspects regulate tumor cell survival, proliferation and migration. In this paper, the structure and related transcription factors of PGC-1αwere reviewed. The mechanism of PGC-1αmetabolism in tumorigenesis and development was discussed, and the progress of PGC-1α in tumor metabolism was emphatically described. -1α as the target of anti-tumor metabolism of basic research and drug development to provide a new theoretical reference.