论文部分内容阅读
本文报道用“抗癫痫药物开发程序”筛选一组新的取代马来酰亚胺类化合物的抗惊活性,发现6个高效化合物。作者还在多种动物模型上观察有效化合物之一的N—乙基对氯苯代马来酰亚胺(YWO16)的抗惊活性。YWO16对抗小鼠戊四氮惊厥的ED_(50)为40.7 mg/kg,
This article reports the screening of a new set of substituted maleimide compounds for anticonvulsant activity using the “Antiepileptic Drug Development Program” and found six highly effective compounds. The authors also observed the anti-shock activity of N-ethyl p-chlorobenzene maleimide (YWO16), one of the active compounds, on various animal models. The ED50 of YWO16 against mice pentylenetetrazole was 40.7 mg / kg,