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目的：观察芬太尼透皮贴剂（多瑞吉）对晚期癌症伴重度疼痛患者的镇痛效果及其不良反应。方法：采用多中心随机自身对照及开放试验设计，对照药选用缓释吗啡片，二种药物均采用滴定法给药原则，至２４ｈ无疼痛或基本不痛为止。多瑞吉ｑ７２ｈ一贴，缓释吗啡ｑ１２ｈ一次。评价指标为疼痛强度、疼痛缓解率、生活质量等。结果：多瑞吉可使患者的疼痛强度降低到３．０以下，中度疼痛缓解率达到１００％，生活质量明显改善。与对照组相比，不良反应略低，但无显著性差异。结论：多瑞吉可有效地控制上述疼痛，不良反应较低，患者接受程度好。
OBJECTIVE: To observe the analgesic effect and adverse reactions of fentanyl transdermal patch (Doric Kyrgyzstan) in patients with advanced cancer with severe pain. Methods: Randomized multicenter randomized controlled trial and open trial design were used. Controlled-release morphine tablets were used. Both drugs were titrated to the principle of no pain or no pain for 24h. Doric q72h a post, slow release morphine q12h once. Evaluation indicators for pain intensity, pain relief rate, quality of life and so on. Results: Doric can reduce the patient’s pain intensity to below 3.0, moderate pain relief rate to 100% and quality of life significantly improved. Compared with the control group, the adverse reaction was slightly lower, but no significant difference. Conclusion: Doric can effectively control these pains with low adverse reactions and good patient acceptance.