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目的探讨胺碘酮与利多卡因对室性心律失常的作用,比较两者在治疗方面的疗效及安全性。方法采用氯化钡(BaCl2)实验性心律失常模型,大鼠舌下静脉注射胺碘酮、利多卡因进行纠正,观察两者的作用时间、再次心律失常时间。结果胺碘酮与利多卡因两种药物均有抗心律失常作用,起效时间无明显差异,但胺碘酮再次出现心律失常的时间(58.11 min±4.96 min)比利多卡因再次出现心律失常的时间(13.33 min±7.60 min)迟得多,差异有统计学意义(P<0.01)。结论胺碘酮在治疗BaCl2引起的室性心律失常方面,比利多卡因作用时间持久、安全性高。
Objective To investigate the effect of amiodarone and lidocaine on ventricular arrhythmia and to compare the curative effect and safety of the two in the treatment. Methods The model of barium chloride (BaCl2) experimental arrhythmia was established. Amiodarone and lidocaine were injected into the sublingual vein of rats to correct them. The duration of action and re-arrhythmia time were observed. Results Both amiodarone and lidocaine had anti-arrhythmic effects, with no significant difference in onset time. However, arrhythmia was again observed after amiodarone (58.11 min ± 4.96 min) and arrhythmia (13.33 min ± 7.60 min), the difference was statistically significant (P <0.01). Conclusions Amiodarone has long-lasting and safe action on lidocaine-induced ventricular arrhythmias compared with lidocaine.