论文部分内容阅读
1993年发现的GDNF（神经胶质源性神经营养因子）是中脑多巴胺能神经元的存活因子。它的发现为治疗帕金森氏病和其它神经元功能紊乱带来了希望，并引起了对其受体的深入研究。由于GDNF与TGF一p有关，因此人们推测GDNF受体可能是TGF-β和其相关因子的跨膜丝氨酸／苏氨酸激酶受体?
GDNF (glial derived neurotrophic factor) found in 1993 is a survival factor of mesencephalic dopaminergic neurons. Its discovery offers hope for the treatment of Parkinson’s disease and other neuronal disorders and has led to an in-depth study of its receptors. Since GDNF is associated with TGF-β, it is speculated that GDNF receptors may be transmembrane serine / threonine kinase receptors of TGF-β and its related factors?