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对β-内酰胺类抗生素耐药的主要机制是β-内酰胺酶,对付的办法是开发对β-内酰胺酶稳定的衍生物.另外考虑将β-内酰胺酶抑制剂与现有的药物联合使用的方法,砜酰胺菌素(Subactam)与氧哌羟苯唑头孢菌素(Cefoperazone)的合剂就是其一.
The main mechanism of resistance to [beta] -lactam antibiotics is [beta] -lactamase, which is to deal with the development of derivatives that are stable to [beta] -lactamase.In addition, consideration is given to combining [beta] -lactamase inhibitors with existing drugs The combination of Subactam and Cefoperazone is one of these methods.