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目的观察健脾益气法治疗小儿频复发肾病综合征的临床疗效,初步探讨其作用机制。方法将72例频复发肾病综合征患儿随机分为2组,对照组采用常规西医治疗,治疗组在此基础上加用健脾益气法治疗,比较2组的复发次数、尿β2-微球蛋白(β2-MG)、免疫球蛋白(Ig A,IgG)、血浆胆固醇及血浆皮质醇、复发后尿蛋白转阴时间及完全缓解时间。结果治疗组1年复发次数、尿β2-MG、血浆胆固醇均低于对照组(P<0.05);免疫球蛋白和血浆皮质醇高于对照组(P<0.05);复发后治疗组尿蛋白转阴时间短于对照组,完全缓解时间长于对照组,差异均有统计意义(P<0.05)。结论健脾益气法参与小儿频复发肾病综合征的治疗具有较好的临床效果,其机制可能与改善免疫功能、提高肾上腺皮质功能、改善高脂血症等多种途径密切相关。
Objective To observe the clinical effects of invigorating the spleen and invigorating Qi on children with frequent recurrent nephrotic syndrome and to explore its mechanism. Methods 72 cases of recurrent nephrotic syndrome were randomly divided into two groups. The control group was treated with routine western medicine. The treatment group was treated with the method of invigorating the spleen and invigorating Qi, and the relapse frequency, urinary β2-micrometastasis Globulin (β2-MG), Ig A (IgG), plasma cholesterol and plasma cortisol, urinary protein negative relapse time and complete remission time after relapse. Results The number of relapse, urine β2-MG and plasma cholesterol in the treatment group were lower than those in the control group (P <0.05), and the immunoglobulin and plasma cortisol levels were higher in the treatment group than those in the control group (P <0.05) The duration of complete remission was longer than that of the control group, with significant difference (P <0.05). Conclusion The method of invigorating the spleen and invigorating Qi in treating infantile recurrent nephrotic syndrome has a good clinical effect, and its mechanism may be closely related to many ways such as improving immune function, improving adrenocortical function and improving hyperlipidemia.