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目的:探讨CD44V6在眼附属器淋巴瘤中的表达及意义。方法:采用免疫组化S-P法检测63例眼附属器淋巴瘤中CD44V6的表达情况。其中弥漫性大B细胞淋巴瘤(DLBCL)22例,首次诊断为DLBCL12例,原发性黏膜相关淋巴组织(MALT)淋巴瘤复发演变为DLBCL10例;MALT淋巴瘤41例,26例为初发病例,15例为复发病例;另选10例眼附属器淋巴组织反应性增生病例作对照。结果:CD44V6阳性者细胞膜呈棕色。CD44V6在DLBCL的表达率和阳性程度均比MALT淋巴瘤高,差异有统计学意义(P<0.05);CD44V6在淋巴瘤中的表达率和阳性程度比淋巴组织反应性增生高,差异有统计学意义(P<0.05),但在DLBCL和MALT淋巴瘤各自组内的表达率和阳性程度均无有统计学差异(P>0.05)。CD44V6表达与患者的年龄、性别均无关。结论:在眼附属器淋巴组织异常增生疾病中,CD44V6的表达随病变程度加重而增强,提示其在眼附属器MALT淋巴瘤的发生和发展中起重要作用。
Objective: To investigate the expression and significance of CD44V6 in adnexal lymphoma. Methods: The immunohistochemical S-P method was used to detect the expression of CD44V6 in 63 cases of adnexal lymphoma. Among them, 22 cases of diffuse large B-cell lymphoma (DLBCL) were diagnosed as DLBCL for the first time in 12 cases and 10 cases of DLBCL recurrence in primary mucosa-associated lymphoid tissue (MALT) lymphoma; 41 cases of MALT lymphoma and 26 cases of initial cases , 15 cases of recurrent cases; another 10 cases of adnexal lymphoid tissue hyperplasia cases as a control. Results: The membrane of CD44V6 positive cells was brown. The positive rates of CD44V6 in DLBCL were higher than those in MALT lymphoma (P <0.05). The positive rate of CD44V6 in lymphoma was higher than that in lymphoid tissue (P <0.05), but there was no significant difference between the two groups (P> 0.05). CD44V6 expression was not related to the patient’s age and gender. Conclusion: The expression of CD44V6 in patients with ocular adnexal lymphoid dysplasia is increased with the severity of the lesion, suggesting that CD44V6 plays an important role in the pathogenesis and development of ocular adnexal MALT lymphoma.