The variations of regional mean daily precipitation extreme (RMDPE) events in central China and associated circulation anomalies during June, July, and August (JJA) of 1961-2010 are investigated by using daily in-situ precipitation observations and the NCEP/NCAR reanalysis data. The precipitation data were collected at 239 state-level stations distributed throughout the provinces of Henan, Hubei, and Hunan. During 1961-2010, the 99th percentile threshold for RMDPE is 23.585 mm day-1. The number of RMDPE events varies on both interannual and interdecadal timescales, and increases significantly after the mid 1980s. The RMDPE events happen most frequently between late June and mid July, and are generally associated with anomalous baroclinic tropospheric circulations. The supply of moisture to the southern part of central China comes in a stepping way from the outer-region of an abnormal anticyclone over the Bay of Bengal and the South China Sea. Fluxes of wave activity generated over the northeastern Tibetan Plateau converge over central China, which favors the genesis and maintenance of wave disturbances over the region. RMDPE events typically occur in tandem with a strong heating gradient formed by net heating in central China and the large-scale net cooling in the surrounding area. The occurrence of RMDPE events over central China is tied to anomalous local cyclonic circulations, topographic forcing over the northeast Tibetan Plateau, and anomalous gradients of diabatic heating between central China and the surrounding areas.