葡萄糖注射液为临床输液疗法中常用的制剂,生产实践中葡萄糖注射液经灭菌后,有时出现颜色变黄、pH 值下降现象。已证实,在弱酸性条件下,葡萄糖分子内脱去一分子水生成3-脱氧己糖(3-deoxyhesxo-sone),经分子重排形成偏变糖酸(metasa-ccharinic acid),再经分子内脱水则生成5-羟甲基糠醛(5-hydroxymethylfu-rral,简称5-HMF),5-HMF 进一步分解为乙酰丙酸和甲酸或聚合物。5-HMF Glucose injection is a commonly used preparation for clinical infusion therapy. After the glucose injection is sterilized in production practice, yellowing and pH drop sometimes occur. It has been confirmed that under weak acid conditions, 3-deoxyhesxo-sone is formed in glucose molecules to form 3-deoxyhesxo-sone, rearranges to form metasa-ccharinic acid, Internal dehydration generates 5-hydroxymethylfuraldehyde (5-HMF), 5-HMF further decomposition of levulinic acid and formic acid or polymer. 5-HMF