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按Deichmenn,Le Blauc法,给犬单次iv青蒿酯钠,给药后观察14d。结果表明:无毒副反应的最大剂量(MTD)为70mg/kg,近似致死量(ALD)为240mg/kg。毒副作用的主要表现为胃肠道和神经系统症状,致死剂量还引起肉眼血尿。化验检查以网织红细胞减少和血浆ALP升高发生最早,变化明显。病理损伤按出现所需剂量由小到大为红系造血抑制,内脏淤血,胆汁淤滞,胃肠粘膜坏死,肠道出血及肝,肾实质细胞退行性变,量效关系显著。33mg/kg未见任何毒副作用,可视为安全界量。
According to Deichmenn, Le Blauc law, give dog a single iv artesunate sodium, 14d after administration. The results showed that the maximum toxic dose (MTD) was 70mg / kg and the approximate lethal dose (ALD) was 240mg / kg. Toxic side effects of the main manifestations of gastrointestinal and nervous system symptoms, lethal dose also caused gross hematuria. Laboratory tests to reticulocyte reduction and plasma ALP occurred the earliest changes significantly. Pathological damage by the required dose from red blood hematopoietic inhibition, visceral congestion, cholestasis, gastrointestinal mucosal necrosis, intestinal bleeding and liver and kidney parenchymal cells degeneration, the dose-effect relationship was significant. 33mg / kg did not see any side effects, can be regarded as the safety margin.